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Products – InQu

InQu Bone Graft Extender and Substitute combines the structural and biological attributes of poly(lactide-co-glycolide) (PLGA) and hyaluronic acid (HyA), two biomaterials with a long history of safe and effective clinical use. InQu’s unique scaffold creates a product with a microenvironment that is both biocompatible and conducive to new bone formation. PLGA imparts the three-dimensional structure to InQu, and provides a reliable resorption rate at the site of implantation. HyA is reported to play a critical role in tissue regeneration and repair (1). In addition, HyA is known to aid essential early events in bone formation by promoting the migration, proliferation, and differentiation of osteogenic cells (2-4).

While there are many synthetic products in the market serving as bone graft substitutes, InQu Bone Graft Extender and Substitute offers physicians important surgical advantages. Unlike other bone graft substitutes, which are slowly replaced during osteoclastic remodeling, InQu supports the normal process of endochondral bone formation. In addition, the rate of InQu resorption and replacement appears equal to the rate of bone remodeling. The combination of PLGA and HyA provides the surgeon with superior cohesiveness, molding properties and handling characteristics to yield consistent, predictable results.

InQu is available in Paste Mix (2.5, 5, and 10 cc), Matrix (5×5 cm and 5×10 cm), or Granules (10 and 30 cc). InQu can be prepared using a pre-measured quantity of saline or equivalent amounts of an appropriate patient-derived bodily fluid such as bone marrow aspirate concentrate.

Description of PDF: Comparative Study of InQu® Bone Graft Extender & Substitute and Tricalcium Phosphate (TCP) for Posterolateral Lumbar Fusion: Retrospective Comparative Data Analysis

Indication for Use Statement

InQu is a resorbable bone void filler intended to fill bony gaps or voids that are not intrinsic to the stability of the bony structure. InQu is intended for use as a bone graft substitute in the skeletal system (extremities and pelvis), and as a bone graft extender in the spine when combined with bone autograft. These defects may be surgically created or result from traumatic injury to the bone.

Footnotes:
1. Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Rep Regen 1999; 7:79-89.
2. Hall CL, Wang C, Lange LA, Turley EA. Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity. J Cell Biol 1994; 126:575-588.
3. Sasaki T, Watanabe C. Stimulation of osteoinduction in bone wound healing by high-molecular weight hyaluronic acid. Bone 1995; 16:9-15.
4. Huang L, Cheng YY, Koo PL, et al. The effect of hyaluronan on osteoblast proliferation and differentiation in rat calvarial-derived cell cultures. J Biomed Mater Res 2003; 66:880-884.